Cortexonomics exhibits that brain - cortex behaves differently when facing nature or human actors. Few management investigators are passionate to study character of Cortexonomics in economic choice making dynamics. Cortexonomics translational research arranges for new way of computing entrepreneurial economic choice. ‘Inferential’ information and neuroscientific representations stimulate to start a fresh inquiry with tests economic choice observables and computational (neural) mechanisms. Motivation prompted to explore links between entrepreneurial economic choice making and neuroscience. It was significant to arrive at a conclusion that neuroscience and Cortexonomics follow ‘Biological Plausibility’ (causal connection between presumed origin and outcome that is unswerving with prevailing biotic understanding). The era of Cortexonomics has arrived to develop theoretical models, based on axiomatic foundation of eye movements and blood monikers, which can predict entrepreneurial economic choices.